A smiling Ross Lyon has confirmed star defender Matt Maguire will make his long-awaited comeback for St Kilda in this weekend's crunch match against Collingwood.

And the Saints coach could include another key big man in the 22 with Justin Koschitzke more likely to play than the 'one per cent' possibility Lyon gave him on Thursday.

Maguire, along with former skipper Aaron Hamill, resumed in the VFL last weekend with Casey.

Both got through unscathed and Maguire's impressive display was enough to convince St Kilda selectors.

"Aaron returned and he kicked four goals which was fantastic for Aaron and Casey. He'll train tonight and if he continues to go well he'll play for Casey again," Lyon told a large media pack at Moorabbin on Thursday afternoon.

"Matty Maguire did a full pre-season, virtually, and played round one, he's been running for a fair while longer. He made a good return so if he gets through tonight we are pretty excited about playing him."

The Saints trained behind closed doors at Moorabbin on Thursday ahead of Saturday's MCG date with the Magpies.

Maguire was on the track early and looked free during the warm-up which pleased Lyon.

"It's been a 13-week absence (for Maguire). He's a really bubbly and enthusiastic leader of the team so we're rapt at the thought of him coming back," Lyon said.

"It's great for 'Goose' but we just want him to play a part."

Hamstring victim Koschitzke had not appeared as early as Maguire, but the feeling is he may be a surprise inclusion.

"He'll do a little bit tonight. There's a one per cent chance (he'll play). It was a hamstring that he injured against Fremantle and it was on the lower end of the scale and (it) had a little bit to do with his back," a coy Lyon said.

"If I was a betting man I would say no, but there's a slim chance he could get through and be available for selection."