Norwegian league leaders Stabaek stunned French side Rennes with a 2-1 win in the first leg of their UEFA Cup second qualifying round clash on Friday morning.
Mike Kjolo was on target twice for Stabaek before Moussa Sow pulled one back to give the Ligue 1 side hope heading into the second leg in a fortnight's time.
Goals from Serdar Tasci and Ciprian Marica helped Stuttgart earn a 2-1 advantage at home to Hungarian side Gyor, while the other Bundesliga team in action - Hertha Berlin - managed a 2-0 triumph at Interblock Ljubljana of Slovenia thanks to Marko Pantelic's double.
There were mixed fortunes for the two English sides in action with Aston Villa recording a convincing 4-1 triumph at Hafnarfjordur - Liverpool target Gareth Barry among the scorers - but Manchester City going down 1-0 at home to FC Midtjylland.
Spanish side Deportivo La Coruna have work to do after managing only a goalless draw in the home leg of their tie against Croatian outfit Hajduk Split.
Inacio Pia struck twice as Serie A side Napoli ran out 3-0 winners at Albanian minnows Vllaznia.
Brondby and Lech Poznan all but booked their berths in the first round proper with 4-0 and 6-0 wins over Haka Valkeakoski and Grasshoppers respectively, while Young Boys overcame Debrecen 4-1 and Salzburg stormed to victory by the same scoreline at Suduva.
The tie between Legia Warsaw and FC Moscow is finely poised after the Russian side's 2-1 win in Poland, while Djurgarden against Rosenborg is also far from decided following the Swedish team's 2-1 home triumph in the first leg.
UEFA Cup, Second Qualifying Round results (first leg)
L. Metalurgs 0
FC Vaslui 2
N'Doye 69, Genchev 73
Borac C. 1
Pavlovic 48
Lokomotiv Sofia 0
Honka 0
Viking 0
Vojvodina Novi Sad 0
Hapoel Tel Aviv 0
Haka Valkeakoski 0
Brondby 4
Rasmussen 30, Lorentzen 70, Williams 86, Madsen 82p
Legia Warsaw 1
Roger 64
FC Moscow 2
Cesnauskis 52, Samedov 63
Stuttgart 2
Tasci 13, Marica 33
Gyor 1
Boor 45
APOEL Nicosia 2
Broerse 34, Zewlakow 47
Red Star Belgrade 2
Edgar 8, Burzanovic 62
Djurgarden 2
Oremo 36, Nazare 89
Rosenborg 1
Sapara 75
Elfsborg 2
Ishizaki 24, Karlsson 28
St. Patricks 2
Quigley 58p, Dempsey 82
Litex Lovech 0
Hapoel Kiryat Shmona 0
Stabaek 2
Kjolo 37, 71
Rennes 1
Sow 77
Suduva 1
Luksys 31
SV Salzburg 4
Sekagya 42, Janko 57p, 61p, Mahop 72
Young Boys Bern 4
Schneuwly 41, 77, Regazzoni 68, 87
Debrecen 1
Rudolf 17
AA Gent 2
Thijs 61, Azofeifa 85
Kalmar 1
Ingelsten 80
Aris Saloniki 1
Koke 55
Slaven Belupo 0
Dnipro D'petrovsk 3
Kalinichenko 11, Nazarenko 48, Kornilenko 79
Bellinzona 2
Kalu 64, Sermeter 75p
FC Copenhagen 3
Santin 2, Junior 79, Nordstrand 86
Lillestrom 1
Kippe 90
Hafnarfjordur 1
Gudmundsson 45
Aston Villa 4
Barry 4, Young 7, Agbonlahor 38, Laursen 64
Liberec 1
Frejlach 85
Zilina 2
Silva 45, Jez 60
Maccabi Netanya 1
Kioyo 27
Cherno More Varna 1
Alex 42
Zurich 1
Hassli 16
Sturm Graz 1
Haas 78p
AEK Athens 0
Omonia Nicosia 1
Cafu 40
Siroki Brijeg 1
Silic 90
Besiktas 2
Delgado 19, Nobre 83
Vllaznia 0
Napoli 3
Pia 28, 46, Denis 75
Braga 1
Linz 67
Zrinski 0
Interblock 0
Hertha BSC 2
Pantelic 16, 82
Lech Poznan 6
Rengifo 5, Lewandowski 14, 56, Vallori 76og, Injac 84, Peszko 88
Grasshoppers 0
Manchester City 0
FC Midtjylland 1
Olsen 15
Queen of the South 1
O'Connor 26
FC Nordsjaelland 2
Kibebe 2, Bernier 32
Deportivo La Coruna 0
Hajduk Split 0