Eli Manning and the New York Giants turned in another dominant performance as they made up for several poor performances against Seattle through a 44-6 ambush.
Manning threw two touchdown passes and Brandon Jacobs scored on a pair of short runs on Sunday as the Giants came off their bye week with a thorough thrashing of the Seattle Seahawks.
The Giants (4-0) are off to their best start since the 1990 season, when they won their first nine games en route to a 13-3 record and the franchise's second Super Bowl championship.
Just behind the Giants on the NFC East standings, Washington improved to 4-1 through a 23-17 victory over Philadelphia.
Clinton Portis rushed for 145 yards from 29 carries and crossed for a touchdown as the Washington Redskins recovered from going 14 points down to defeat the Eagles.
Terrell Owens, meanwhile, caught a 57-yard touchdown pass and helped the Dallas Cowboys, third on the NFC East table, survive a late surge by the Cincinnati Bengals in a 31-22 victory.
In the AFC East division, Kurt Warner threw for 250 yards and two touchdowns as the Arizona Cardinals routed the Buffalo Bills 41-17 after young Buffalo quarterback Trent Edwards left the game with a concussion when he was drilled into the turf after completing a pass to James Hardy on Buffalo's opening possession.
Matt Cassel threw for 259 yards and a score and Kevin Faulk rushed for two touchdowns as the New England Patriots rebounded from an embarrassing loss to Miami, defeating the San Francisco 49ers 30-21.
For Miami, Ronnie Brown rushed for 125 yards and a touchdown to help lead the Dolphins past the San Diego Chargers in a 17-10 result on Sunday.
It was Brown's second straight game with at least 100 yards, following a 113-yard effort in his last game against New England.
The Dolphins, who improved to 2-2 after going 1-15 in 2007, made it two straight victories over the teams who appeared in last season's AFC title game.
AFC North leader Pittsburgh needed Ben Roethlisberger to shoulder the load, and he came through big time.
Roethlisberger hit Hines Ward for a go-ahead touchdown with 1:53 left in the fourth quarter to help the Pittsburgh Steelers to a 26-21 victory over the Jacksonville Jaguars.
The Steelers (4-1) entered the game minus their top two running backs but got a huge game from Roethlisberger, who completed 26-of-41 passes for 309 yards with three touchdowns. It was his first 300-yard game since November 6, 2007.
Tennessee quarterback Kerry Collins tossed an 11-yard touchdown pass to Alge Crumpler with 1:56 remaining as the Titans rallied to maintain their unbeaten start to the season against Baltimore on Sunday in a 10-13 result.
Thwarted most of the day by Baltimore's defence, Collins overcame two early interceptions to drive the Titans (5-0) 80 yards for the winning score.
A stunning collapse by the Houston Texans may have enabled the Indianapolis Colts to get their season back on track as they piled on 21 points in the final four minutes to stun their hosts 21-27.
The Colts (2-2) took advantage of two fumbles by Sage Rosenfels to get back into the contest before Peyton Manning capped the comeback with a five-yard touchdown pass to Reggie Wayne with 1:54 left.
Kyle Orton threw for a career-high 334 yards and a pair of touchdowns and the Chicago Bears used another dominant defensive performance